My Outpouring post on the new injectable type 2 diabetes drug Victoza is in the running for one of the almost-commented-e'er blog posts here at the 'Mine.  Over 100 people now taking the medication have chimed in.

Victoza, for the unfamiliar, is a new once-day-after-day form of the new-generation GLP-1 drugs that stimulate pancreas cells to release insulin in citizenry with type 2 diabetes. Information technology's a head-to-head competitor with the injectable drug Byetta, and both take the happy side do good of aiding weight going.

The comment weave, for somebody like me World Health Organization's on insulin only and no strange diabetes drugs, is frankly kind of scary. Readers complain piercingly about nausea (mild to "horrendous"), vomit, headaches, and severe constipation. A few patients aforesaid they've intimate "painful welts developing at my injection site" — although others said they only got those with Byetta.

Boy, if my diabetes meds made Pine Tree State that scummy, I'd personify off them in a second! The big stomach reaction is one of the chief reasons I've ne'er even well-advised Symlin (with a nod to the ever-brave-and-much-longer-type 1-than-me Kerri, debating it now).

Only despite all the crappy effects, the folks unselfish their Victoza experiences look to agree that the results are worth the discomforts. Victoza is apparently really impressive at safekeeping BG levels down, even after a large meal. And it's a strong appetite suppressant, allowing people who've been struggling for years to finally thin — reportedly from around 6 pounds functioning to 75 pounds! Whatever even compared it to lapband surgery.

Most users are very enthusiastic, notwithstanding concerns about doctors upping their dosage.  Patients are usually started off at a 0.6 mg dose, and so gradually increased to 1.2 Mg, and eventually to a 1.8 mg daily dose.

A lector here titled Sarah writes: "My Endo said the Victoza might have complicated the colitis that I was just hospitalized for because information technology sack have loose bowels…. (but) contempt the lateral effects, I'm sticking with Victoza. I haven't weighed this amount for 6 long time. I want to see where this goes."

And run down this good word blog post on "Triumph with Victoza." Los Angeles resident Selena says with Victoza, she can finally eat breakfast cereal grass again. (Hey, that's a big quite a little for people with diabetes! How I miss cereal myself — sends me into the stratosphere)

bNet Concern Web reports:

"More doctors are prescribing Victoza to patients alternatively of Byetta. The latest weekly statistics reveal that the total of new Victoza prescriptions increased by another 13.6 percentage to 7,232, spell the sum up number of new prescriptions increased past 15 percent to 12,163. More smashing news for Novo, less so for the Byetta franchise unreal by Amylin and Lilly."

I improbable it was primarily the less-injections-required helping Victoza to overtake Byetta in the grocery store. But bNet explains at that place's more to IT:

"Notwithstanding its premium pricing (top dose is about 50% more costly than Byetta) and a weaker formulary status, Novo sales reps have been successful in communicating benefits unique to Victoza:

  • Once-daily shot versus doubly daily for Byetta;
  • Thomas More flexible dosing: Byetta must glucinium dosed (at least) single hour before the daybreak and eve meal – whereas, Victoza can be injected at anytime during the Clarence Shepard Day Jr.;
  • Private clinical trial run, Confidential information-6 (published in The Lancet, demonstrating improved glucose control and lower berth incidence of nausea (amended tolerated) than the exising formulation of Byetta; and,
  • No relate 'tween Victoza and pancreatitis."

These ii drugs will before long have symmetrical more competition, erstwhile Roche's new GLP-1 called taspoglutide (held up for ascending to 18 months due to hypersensitivity problems in trial subjects) and GlaxoSmithKline's parvenue Syncria (operating theater albiglutide, also a once-weekly injection — straight off in previous-stage trials) hit the market.

And I suppose they'll have the same effect: causing nausea — and at the cookie-cutter clock euphoria — wherever they go.

Note: For much background info on Victoza, see this interview with the manufacturer at ASweetLife.com.